ANTICONVULSANT ACTIONS OF THE PUTATIVE γ-AMINOBUTYRIC ACID (GABA)-MIMETIC, ETHYLENEDIAMINE
نویسندگان
چکیده
منابع مشابه
Production of gaba (γ – Aminobutyric acid) by microorganisms: a review
GABA (γ-aminobutyric acid) is a four carbon non-protein amino acid that is widely distributed in plants, animals and microorganisms. As a metabolic product of plants and microorganisms produced by the decarboxylation of glutamic acid, GABA functions as an inhibitory neurotransmitter in the brain that directly affects the personality and the stress management. A wide range of traditional foods p...
متن کاملSubstrate Selectivity of the Acid-activated Glutamate/γ-Aminobutyric acid (GABA) Antiporter GadC from Escherichia coli*
GadC, a central component of the Escherichia coli acid resistance system, is a Glu/GABA antiporter. A previous structural study and biochemical characterization showed that GadC exhibits a stringent pH dependence for substrate transport, with no detectable activity at pH values above 6.5. However, the substrate selectivity and the mechanism of pH-dependent transport activity of GadC remain enig...
متن کاملGamma-Aminobutyric Acid (GABA) Monograpy
Introduction Gamma-aminobutyric acid (GABA) is a major neuro transmitter widely distributed throughout the central nervous system (CNS). Because too much excitation can lead to irritability, restlessness, insomnia, seizures, and movement disorders, it must be balanced with inhibition. GABA – the most important inhibitory neurotransmitter in the brain – provides this inhibition, acting like a “b...
متن کاملSynthesis of γ - Aminobutyric Acid ( GABA ) by Lactic Acid Bacteria Isolated from Italian 1 Cheese Varieties 2 Running title : Lactic Acid Bacteria and γ - Aminobutyric Acid
* Corresponding author. Maria De Angelis, Dipartimento di Protezione delle Piante e 13 Microbiologia Applicata, Facoltà di Scienze Biotecnologiche di Bari, Via G. Amendola 165/a, 14 70126 Bari, Italy. Phone: ++ 39 080 5442948; Fax: ++ 39 080 5442911; E-mail: 15 [email protected] 16 17 AC CE PT ED Copyright © 2007, American Society for Microbiology and/or the Listed Authors/Institutions. ...
متن کاملLocalization of the Sites of Γ-aminobutyric Acid (gaba) Uptake in Lobster Nerve-muscle Preparations
The principal sites of gamma-aminobutyric acid (GABA) uptake in lobster nerve-muscle preparations have been determined with radioautographic techniques after binding of the amino acid to proteins by aldehyde fixation. Semiquantitative studies showed that about 30% of the radioactive GABA taken into the tissue was bound to protein by fixation. Both light and electron micrographs showed dense acc...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1982
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1982.tb09327.x